The Covid-19 Pandemic: Manifestations and Complications of Neurological Disorders
Abstract
In late December 2019, an outbreak of a novel coronavirus causing severe acute respiratory syndrome (SARS) was reported in Wuhan, Hubei Province, China. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic resemblance to the virus SARS-CoV-1 responsible for SARS epidemic almost 20 years before. The epidemic has since spread to much of the world, having been considered as a pandemic with over 12 million confirmed cases and 5,52,143 deaths worldwide till July 10, 2020. COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. Initially thought to be restricted to the respiratory system, it is now understood that COVID-19) also affects other multiple organs, including the central and peripheral nervous system. The number of recognized neurologic manifestations of SARS-CoV-2 infection is rapidly increasing. The pathobiology of the COVID-19 in CNS is still not known. Of the neurological disorders, some appear to be the consequence of direct viral invasion of the tissues of nervous systems, others arise as a postviral autoimmune process, and still, others are the result of metabolic and systemic complications due to the associated critical illness. This review deals with the preliminary observations regarding the neurological disorders reported with COVID-19 to date and illustrates some of the disorders that are anticipated from prior experience with similar coronaviruses.
Keywords: Clinical symptoms, Neurological diseases, Coronavirus, SARS-CoV-2, Stroke
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Copyright (c) 2020 Das Dolan, Das Dolan, Das Dolan
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