Impact of Heavy metal, Arsenic trioxide on Biochemical profile of teleost, Clarias batrachus (Linn.)
Keywords:
Arsenic trioxide, Clarias batrachus, Lethal concentration, Acid phosphatase, Alkaline phosphataseAbstract
The present investigation aims at evaluating the toxic effect of heavy metal, Arsenic trioxide on biochemical profile of Clarias batrachus after 30, 45 and 60 days of post treatment with experimental chemical , arsenic trioxide. Lc 50 value calculated for sublethal study of arsenic trioxide was 8.7 mg/l. Following biochemical parameters were analysed: Serum Protein, Serum Cholesterol. Serum Glucose, Acid phosphatase and Alkaline phosphatase. Decrease in serum protein observed in present study was due to liver cirrhosis or nephrosis. Increase in cholesterol indicated environmental stress in Clarias batrachus .The significant reduction in plasma glucose levels during acute treatment indicates hypoxic condition. Increased stimulation of alkaline phosphatase corresponds to pathological processes as liver impairment, kidney dysfunction and bone disease.
Downloads
References
Agrawal MK and Sastry KV (1979) HgCl2 induced enzymological changes in kidney and ovary of a teleost fish, Channa punctatus Bull. Environ. Contamination Toxico, 22(1-2): 38-43.
Baskaran P, Palanichamy S, Visalakshi S, Balasubramanian MP (1989) Effects of Mineral fertilizers on survival of the fish Oreochromis mossambicus. Environ. Ecol, 7: 463-465. Emsley J (2001) Nature's Building Blocks: An A-Z Guide to the Elements. Oxford:Oxford University Press. pp. 43: 513,- 529.
Gagnon A, Jumarie C, Hontela A (2006) Effects of Cu on plasma cortisol and cortisol secretion by adrenocortical cells of rainbow trout, Oncorhynchus mykiss. Aquat. Toxicol, 78: 59–65.
Gernhofer M, Pawet M, Schramm M, Muller E and Triebskorn R (2001) Ultrastructural biomarkers as tools to characterize the health status of fish in contaminated streams. J. Aquat. Ecosystem, Stress and Recovery, 8:241-260.
Gill TS and Epple A(1992) Impact of cadmium on the mummichog ,Fundulus heteroclitus and the role of calcium in suppressing heavy metal toxicity, Comp. Biochem. Physiol, 101:519-523.
Gill TS and Epple A (1993) Stress-related changes in hematological Profile of the American eel (Anguillarostrata).Exotoxicology and Environmental Safety, 25: 227-235.
Gill TS, Tewari H and Pandey J (1991) In vivo and in vitro effects of cadmium on selected enzymes in different organs of the fish, Barbus conchonius Ham. (Rosy barb) Comp. Biochem. Physiol, 100: 501-505.
Gonzalez HO, Roling JA,Baldwin WS and Bain LJ (2006) Physiological changes and differential gene expression in mummichogs (Fundulus heteroclitus) exposed to arsenic. Aquat. Toxicol, 77:43–52.
Ilyas F, Quazi S, Feroz I , Sairy A and Hashmi S (2007) Effect of heavy metal mercuric chloride on the enzyme alkaline phosphatase from fish.Labeo rohita. J. Aqua. Biol, 22(2): 142-144.
Jatyajit Hota (1996) Arsenic toxicity to the brain, liver and intestine on a freshwater fish.Channa punctatus (Bloch). Geobios, 23 :154 -156.
Jana S and Bondyopadhayay( 1981) Efficacy of heavy metal on some biochemical parameters in the fresh water fish, Channa punctatus Environ Ecol, 5: 488- 493.
Jyothi B and Narayan G (1999) Certain pesticide induced carbohydrate metabolic disorders in the serum of freshwater fish Clarias batrachus (Linn). Food and Chemical Toxicology, 37: 417-421. Luskova V (1997) Annual cycles and normal values of hematological parameters in fishes. Acta Sc. Nat.Brno, 31(5): 70-78.
Murray RK (1991) Harpers Biochemistry 22nd edition Prentice Hall International Inc pp : 678.
Nandi D, Patra RC and Swarup D (2005) Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology ,211:26–35.
Palaniappan PLRM and VijayasundurumV (2009) The effect of arsenic exposure and effect of DMSA on protein and lipids of the gill tissues of Labeo rohita. Food.Chem.Toxicol,47:1752-1759.
Pazhanisamy K (2002) Studies on the impact of Arsenic on a fresh water fish, Labeo rohita (Hamilton). Annamalai university.
Ranjeeta (2008) Endosulfan toxicity induced alterations in some biochemical parameters of the blood and surface ultrastructure of gill of Clarias batrachus (Linn). Ph. D Thesis,Ranchi university,India.
Sastry KV and Gupta PK (1979) Histopathological and enzymological studies on the effects of chronic lead nitrate intoxication in the digestive system of a freshwater teleost, Channa punctatus .Environ Res,17: 472-479.
Sastry KV and Shukla V (1994) Acute and chronic toxic effects of cadmium on some haematological, biochemical, and enzymological parameters in the fresh water teleost fish, Channa punctatus. Acta Hydrochim. Hydrobiol, 4: 71–176.
Singh AK and Banerjee TK (2008) Toxic effect of sodium arsenate (Na2HAsO4.7H2O) on skin epidermis of air breathing catfish Clarias batrachus (L.).Veterinarski Arhiv,78 (1):73-88.
Sharma B (1999) Effect of carbaryl on some biochemical constituents of the blood and liver of Clarias batrachus ,a fresh- water teleost. J. Toxicol. Sci.24(3):157-164
Tamaki S and Frankenbeger WT (1992) Environmental biochemistry of arsenic. Rev Environ Contam Toxicol , 124: 79-110.
Tseng C (2004) The potential biological mechanisms of arsenic- induced diabetes mellitus. Toxicol. Appl. Pharmaco, 197:67-83.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If the material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/