Role of Heat Shock Protein – 70 in the etiology of Idiopathic Pulmonary Arterial Hypertension

Authors

  • Chaitra KL Department of Genetics, Osmania University, Hyderabad – 500007
  • Satyanarayana ML Department of Genetics, Osmania University, Hyderabad – 500007
  • Vadapalli Shivani Department of Genetics, Osmania University, Hyderabad – 500007
  • Manchineela Sairam Department of Genetics, Osmania University, Hyderabad – 500007
  • Bhukya Chaitanya Kumar Department of Genetics, Osmania University, Hyderabad – 500007
  • Sastry BKS Care Hospitals, Nampally, Hyderabad – 500001
  • Nallari Pratibha Department of Genetics, Osmania University, Hyderabad – 500007

Keywords:

Idiopathic Pulmonary Arterial Hypertension, Heat shock proteins, single nucleotide polymorphisms, stress, chaperones

Abstract

Idiopathic Pulmonary Arterial Hypertension is a rare disorder that affects the pulmonary artery, whereby the pressure in the pulmonary artery is increased, culminating in overload on the right ventricle and eventually heart failure. Over the years many studies have been carried out to understand the etiology and to identify the appropriate treatment. This study attempts to contribute to the overall understanding of disease in relation with certain genes that are generally expressed under stress conditions, viz., the heat shock proteins (HSPs). Of this, a prominent group of proteins, HSP70, were identified, to establish a correlation with polymorphisms in these genes and any possible effect on IPAH.

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Published

2017-01-27

How to Cite

Chaitra KL, Satyanarayana ML, Vadapalli Shivani, Manchineela Sairam, Bhukya Chaitanya Kumar, Sastry BKS, & Nallari Pratibha. (2017). Role of Heat Shock Protein – 70 in the etiology of Idiopathic Pulmonary Arterial Hypertension. International Journal of Life Sciences, 4(4), 509–516. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/1334

Issue

Vol. 4 No. 4 (2016): International Journal of Life Sciences

Section

Research Articles

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Copyright (c) 2017 Authors

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