Possible Immunolocalization of Sex-Hormone Binding Globulin (SHBG) in female Labeo rohita
Keywords:
SHBG, estrogen, immunolocalization, bioavailability, Labeo rohitaAbstract
Sex hormone-binding globulin (SHBG) serves as the primary transport protein for sex steroids in the blood of many mammals, other vertebrates, and fish species (Westphal, 1986). Produced mainly in the liver, plasma SHBG controls the bioavailability and metabolic clearance of its bound steroid hormones (Siiteri, 1982). However, in mammals, SHBG gene expression also occurs in various extrahepatic tissues, suggesting potential roles for SHBG beyond the bloodstream (Hammond, 1995). A better understanding of SHBG gene expression patterns is important for clarifying how estrogens act in target tissues during reproduction across different fish species. The present findings indicate that the liver produces SHBG primarily during the reproductive phase in fish. The present study investigated the localization of cellular distribution of SHBG in adult female Indian major carp (L rohita).This work provides insights into the tissue-specific presence of SHBG in a key aquaculture species, building on prior research into its plasma profiles and seasonal variations in this fish. As steroids are progressively utilized and depleted toward the peak of gonadal maturation, the demand for SHBG as a carrier protein may decrease, reducing its levels at that stage and thereby influencing steroid bioavailability.
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