Analgesic and anti-inflammatory activities of methanol tuberous root extract of Decalepis salicifolia (Bedd. ex Hook.f.) Venter
Keywords:
Decalepis salicifolia, anti-inflammatory, analgesic, anti-rheumatoidAbstract
The objective is to study the analgesic and anti-inflammatory activities of methanol extract of tuberous root of Decalepis salicifolia. The analgesic effect was studied using acetic acid-induced writhing and hot plate method in mice and anti-inflammatory effect was investigated using carrageenan, formalin and histamine induced paw edema in rats. In the acute toxicity study, oral median lethal dose (LD50) was found that the extract was non-toxic up to 2000 mg/kg, p.o. The Decalepis salicifolia root extract (50 and 100 mg/kg b.w.) was found to possess, analgesic and anti-inflammatory activities in a dose-dependent manner and related inhibition were achieved in histamine, followed by formalin and the effect was compared with standard drug. The above results will be the supporting evidence for the potential anti-rheumatoid activity of D. salicifolia in our Indian traditional medicine system.
Downloads
References
Amanlou M, Dadkhah F, Salehnia A, Farsam H, Dehpour AR (2005) Anti-inflammatory and antinociceptive effects of hydrochloric extract of Satureja khuzistanica Jamzad extract. Journal of Pharmacy and Pharmaceutical Science. 8:102-106.
Amos S, Kolawole E, Akah P, Wambebe C, Gamaniel K (2001) Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats. Phytomedicine. 8:356-361.
Anon M (1952) The wealth of India. First supplemented series (Raw material). NISC and CSIR, New Delhi, India.
Bentley GA, Newton SH, Starrr J (1983) Studies on the antinociceptive action of agonist drugs and their interaction with opoid mechanisms. Bracilian Journal of Pharma. 79:125-134.
Bittar M, de Souza MM, Yunes RA, Lento R, Delle Monache F and Cechinel-Filho V (2000) Antinoceceptive activity of I3, II8-binaringenin: A biflavonoid present in plants of the guttifera, Planta Med. 66:84.
Castro J, Sasame H, Sussaman H, Butlette P (1968) Diverse effect of SKF52 and antioxidants on CCl4 induced changes in liver microsomal P-450 content and ethyl morphine metabolism. Life Science. 7:129–36.
Chidambara Murthy KN, T Rajasekaran, P Giridhar, GA Ravishankar (2006) Antioxidant property of Decalepis hamiltonii Wight & Arn. Indian Journal of Experimental biology. 44: 832-837.
Dharmasiri MG, Ratnasooriya WD, Thabrew MI (2002) Anti-inflammatory activity of decoctions of leaves and stems of Anisomeles indica at preflowering and flowering stages. Journal of Pharma Biology. 46:433-439.
Ecobichon DJ (1997) The basis of toxicology testing. CRC Press, New York.
Eddy NB, Leimback D (1953) Synthetic analgesics II Dithienylbutenyl and dithienylbutylamines. Journal Pharmacology and Experimental Theory. 107:385-393.
Gulab Khan Rohela, Phanikanth Jogam, Prasad Bylla, Christopher Reuben (2019) Indirect Regeneration and assessment of genetic fidelity of acclimated plantlets by SCoT, ISSR, and RAPD markers in Rauwolfia tetraphylla L.: An Endangered Medicinal Plant. BioMed Research International.1-14. doi.org/10.1155/2019/3698742.
Howland RD, Mycek MJ (2006) Lippincott’s illustration Review: Pharmacology. Harvey RA, Champe PC (eds.) Lippincott Williams and Wilkins publishers, London. Pp. 157-168.
Ibrahim M, Abdulkadir AU, Zezi Zakiyyah, Ibrahim YY, Adamu Abdulrahman, Shehu UF (2017) Immune-mediated Anti-inflammatory Activity of Root Bark Extracts of Calotropis procera (Ait) R.Br. in Rodents. African Journal of Pharmacology and Therapeutics. 6:14-19.
Koster R, Anderson M, DeBeer EJ (1959) Acetic acid for analgesic screening. Federation Proc, 18: 412.
Nagarajan S, Jagan Mohan Rao L, Gurudatt KN (2001) Chemical composition of the volatiles of Decalepis hamiltonii (Wight & Arn). Flavor and Fragrance Journal. 16:27–29.
Naveen S, Khanum F (2010) Antidiabetic, antiatherosclerotic and hepatoprotective properties of Decalepis hamiltonii in Streptozotocin induced diabetic rats. Journal of food and biochemistry. 34:1231-1248.
OECD (1996) OECD Guidelines for the testing of chemicals, Test no. 423; Acute Oral Toxicity - Acute Toxic Class Methods.
Perianayagam JB, Sharma SK, Pillai KK (2006) Anti-inflammatory activity of Trichodesmum indicum root extract in experimental animals. Journal of Ethnopharmacology. 104: 410-414.
Samydurai P, Jagatheshkumar S, Aravinthan V, Thangapandian V (2012) Survey of wild aromatic ethnomedicinal plants of Velliangiri Hills in the Southern Western Ghats of Tamilnadu, India. International Journal of Medicinal and aromatic plants. 2:229-234.
Samydurai P, Thangapandian V (2012) Antioxidant property and polyphenols evaluation of aqueous root extract of Decalepis hamiltonii Wight & Arn. International Current Pharma Journal. 1:71-76.
Samydurai P, V Thangapandian (2012) Physico-phytochemical analysis and their minimum inhibitory concentrations of various extracts of Decalepis hamiltonii Wight & Arn against gastrointestinal disorder pathogens. International Journal of Pharmacy and Pharmaceutical Science. 4:289-292.
Santa-Cecilia FV, Vilela FC, da Rocha CQ, Dias DF, Cavalcante GP, Freitas LAS, Giusti-paiva A (2011) Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis. Journal of Ethnopharmacology. 133:467.
Suleyman H, Demirezer LO, Kuruuzum A, Banoglu ZN, Gocer F, Ozbakir G, Gepdiremen A (1999) Anti-inflammatory effect of the aqueous extract from Rumex patientia L roots. Journal of Ethnopharmacology. 65:141-148.
Suralkar AA, Sarda PS, Ghaisas MM, Thakare VN, Deshpande AD (2008) In vivo animal model for evaluation of anti-inflammatory activity. Pharma Review. 6:2.
Thangavela K, Ebbieb MG, Ravichandran C (2011) Antibacterial potential of Decalepis hamiltonii (Wight & Arn.) callus extract. Nature of pharma tech. 1:14-18.
Turner R (1965) Screening method in pharmacology. Anti-inflammatory agent, Academic Press New York, London, Pp. 158.
Turner RA (1995) Screening methods in Pharmacology, New York: Academic Press, Pp 85-106.
Vane J, Booting R (1987) Inflammation and mechanism of action of anti-inflammatory drugs. FASEB Journal.1:89-96.
Ved Prakash (2017) Terpenoids as source of anti-inflammatory compounds. Asian Journal of Pharma and Clinical Research. 3:68-76.
Vedavathy S (2004) Decalepis hamiltonii Wight & Arn–An endangered source of indigenous health drink. Natural Product Radiance. 3:22-23.
Vogel HG (2002) Drug Discovery and Evaluation. Pharmacological Assays, 2nd ed. New York: Springer, Pp 752.
Winter CA, Risley EA, Nuss CW (1962) Carrageenan induced edema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc Soc Experimental Biology Med. 111:544–547.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Saradha M
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If the material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/
