Endosulfan Induced Male Reproductive changes and their Treatment with Withania somnifera
Keywords:
Endosulfan, Sperm profile, Withania somnifera, Gavage method.Abstract
The ameliorating effect of Withania somnifera was evaluated against changes in sperm profile of mice. The animals received Endosulfan (Pesticide) once daily for 35 days at the dose of 3 mg/kg body wt by oral gavage method and observed toxic effect such as of reduction in the number of sperm and sperm motility which signify the testicular dysfunctions and finally causes infertility. To ameliorate the toxic effect made by endosulfan, Withania somnifera (Ashwagandh) was administered to mice along with its food @ 150 mg/kg body wt. The potent medicinal power like antioxidant, anti-stress, anti-inflammatory, anti-aging, aphrodisiac, astringent, deobstruent, diuretic, narcotic, sedative, anti-tumor and anti-ulcerogenic activities in the root extract of Withania somnifera alleviate the fluctuation in sperm count and sperm motility which was decreased by pesticide treatment.
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