Nerium oleander L.: Phytochemical and pharmacological profile
Keywords:
N.oleander, Phytoconstituents, Pharmacological activity, ToxicityAbstract
Nerium oleander linn. (Apocynaceae) is a beautiful flowering shrub bearing white and crimson flowers especially suited to dry and sunny locations. The plant is commonly called kaner. In view of its therapeutic activities, different parts of the plant have been subjected to chemical studies by various groups of workers, and several cardiac glycosides, pregnane derivatives and polysaccharides have been isolated. N.oleander is a good cardioprotective, anticancer, antidiabetic and antifungal agent. The present review summarizes traditional uses, pharmacological properties of extracts and phytoconstituents of N.oleander.
Downloads
References
Abe F and Yamauchi T (1976) Pregnanes in the Root Bark of Nerium-Odorum. Phytochemistry (Oxford) 15, 1745-8.
Abe F and Yamauchi T (1992) Cardenolides trio sides of nerium oleander leaves. Phytochemistry 31(7), 2459-2463.
Adome RO, Gachihi JW, Onegi B, Tamale J, Apio SO (2003) The cardiotonic effect of the crude ethanolic extract of nerium oleander in the isolated guinea pig hearts. African Health Sciences, 3(2), 77-82.
Ansford AJ, Morris H (1981) Fatal Oleander poisoning. Med J Aust 1, 360-361.
Atay I, Gören AC, Kırmızıbekmez Hasan, Erdem Y (2018) Evaluation of the in vitro anti-inflammatory activity of Nerium oleander L. flower extracts and activity-guided isolation of the active constituents. Records of Natural Products 12, 128-141.
Atiya Z, Bina SS, Sabira B, Salimuzzan S, Amin S (1995) Studies on the constituents of nerium oleander on behaviour patterns in mice. Journal of ethnopharmacology, 49(1), 33-39.
Bai L, Wang L, Zhao M, Toki A, Hasegawa T, Ognra H, Hirose K, Sakai J, Bai J (2007) Bioactive pregnanes from nerium oleander. Journal of Natural Products 70(1), 14-18.
Balkwill F, Charles KA, Mantovani A (2005) Smoldering inflammation in the initiation and promotion of malignant diseases. Cancer Cell 7, 211-217.
Bhuvaneshwari L, Arthy E, Anitha C et al (2007) Phytochemical analysis & Antibacterial activity of Nerium oleander. Ancient science of life 26, 24-8.
Chaudhary K and Prasad DN (2014) A Review on: Nerium oleander Linn. (Kaner) International Journal of Pharmacognosy and Phytochemical Research 6(3), 593-597
Chopra RN, Nayer SL, Chopra IC (1956) Glossary of indian medicinal plants, 175. CSIR, New delhi.
Farooqui S and Tyagi T (2018) Nerium oleander: It's application in basic and applied science: A Review. International Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 1-4.
Farrukh A, Mohammad S, Moammir HA, Hasan M, (2004) Inhibition of 12-o-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. Toxicology and Applied Pharmacology, 195(3), 361-369.
Hase GJ, Deshmukh KK, Murade VD et al. (2016) Phytopharmacology of Nerium oleander L.- A Review. International Journal of Phytopharmacology, 7(2), 63- 67.
Huxley A, Griffiths M, Levy M (1992) The new RHS dictionary of gardening. Mac millan. ISBN 0-333-47494-5.
Jabbar A, Mostqul H, Rashid MA, Hasan CM (1999) A novel antibacterial and cardiac steroid from roots of nerium oleander. Fitotherapia, 70(1), 5-9.
Jain S, Yadav PP, Gill V, Vasudeva N (2009) Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile. Phytochemistry reviews, 8, 491-502.
Judith AS, Timothy M, Mary V, Robert AN (2001) Inhibition of export of fibroblast growth factor (FGF-2) from the prostate cancer cell lines PC-3 and DU-145 by Anvirzel and its cardiac glycoside component oleandrin. Biochemical pharmacology, 62(4), 469-472.
Karawa MS, Balbae SI, Khayyal SE (1973) Estimation of cardenolides in nerium oleander. Planta medica, 23, 70-73.
Kingsbury JM (1964) Poisonous plants of U.S and Canada . Eaglewood cliffs, NJ, Prentice Hall Inc.
Kumar A, De T, Mishra A, Mishra AK (2013) Pharmacognosy Reviews. Oleandrin: A Cardiac Glycosides with Potent Cytotoxicity 7(14), 131-139
Maged MY, Saley NM (2007) Protective potential of glimepiride and nerium oleander extract on lipid profile, body growth rate and renal function in streptozotocin induced diabetes rats. Turk journal of Biology, 31, 95-102.
Malik R, Bokhari T, Siddiqui M et al (2015) Antimicrobial activity of Nerium oleander L. and Nicotiana tabacum L. A comparative study. Pakistan Journal of Botany, 47, 1587-1592.
Man-Shan Y, Anita YW, Kwok FS, Ji F, Wai Y (2007) New polysaccharides from nerium indicum protects neurons via stress kinase signaling pathway. Brain Research, 1153:221-30.
Mwafy SN, Yassin MM (2011) Antidiabetic Activity Evaluation of Glimepiride and Nerium oleander Extract on Insulin, Glucose Levels and Some Liver Enzymes Activities in Experimental Diabetic Rat Model. Pakistan journal of biological sciences, 14, 984-90.
Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P (2007) Autophagic cell death of human pancreatic tumor cells mediated by oleandrin , a lipid soluble cardiac glycoside. Integrative cancer therapy, 6(4), 354-364.
Nurgun, E., Esra, K., Erdem, Y., 2003. Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in turkish folk medicine. Journal of Ethnopharmacology 89(1), 123-129.
Osman, G., Ramazan, M., Duru, M.E., Ertan, O., Melda, C., 2007. Application of extracts from the poisonous plant nerium oleander linn. As a wood preservative. African journal of biotechnology 6(17), 2000-2003.
Qamar KA, Farooq AD, Siddiqui BS, Kabir N et al (2017) Antiproliferative Effects of Nerium oleander Leaves and Its Cardiac Glycosides OdorosideA and Oleandrin on MCF-7 Cancer Cells. Current Traditional Medicine, 3(2).
Rahman G, Ishtiaq M (1997) Effect of different soil media and planting time on the growth of aerial plant parts of Nerium odorum. Sarhad Journal of Agriculture, 13, 263-7.
Rheiner A, Hunger A, Reichstein T (1952) Glykoside und Aglykone. 95. Die Glykoside von Nerium odorum Sol. 3. Die Konstitution von Odoroside G. Helv. Chim Acta 35, 687-716.
Rout SK, Kar MK, Rout B (2012) Study of CNS activity of leaf extracts of Nerium oleander in experimental animal models. International Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 378-382.
Sabira B, Bina SS, Razia S, Atiya Z, Amin S (1999) Bioactive cardenolides from the leaves of nerium oleander. Phytochemistry, 50(3), 435-438.
Satyanarayana T, Prasad PP, Devi MV, Rao RV (1975) Phytochemical Studies on Nerium-Odorum Root Bark. Indian Journal of Pharmacy, 37, 126-7.
Shaw D, Pearn J (1979) Oleander poisoning. Med J Aust., 2, 267-269.
Siddiqui BS, Sultana R, Begum S, Zia A, Suria A (1997) Cardenolides from the methanolic extract of nerium oleander leaves possessing central nervous system depressant activity in mice. Journal of Natural Products, 60(6), 540-44.
Siddiqui S, Hafeez F, Begum S, Bina SS (1987) Isolation and structure of two cardiac glycosides from the leaves of nerium oleander. Phytochemistry, 26(1), 237-241.
Singhal, K.G., Gupta, G.D. 2011. Some central nervous system activities of Nerium oleander Linn (Kaner) Flower Extract. Tropical Journal of Pharmaceutical Research., 10 (4).
Tarun, N., Akgun, D., Kuruca, S.E., Kilicaslan, T., 2006. Cytotoxic effects of leaf, stem and root extracts of nerium oleander on leukemic cell lines and role of P-glycoprotein in this effect. J Exp Ther Oncol 6(1), 31-38.
Vinoth KA (2020) Anti-inflammatory and antibacterial activity of nerium oleander. International Journal of Life Sciences and Pharma Research, 46-53.
World health organization 2006, Diabetes Programme , Department of chronic diseases and health promotion : Facts and figures sheet- Diabetes, Geneva, Switzerland.
Yamauchi T, Abe F (1992) Two pregnanes from oleander leaves. Phytochemistry 31(8), 2819-2820.
Yamauchi T, Ehara Y (1972) Nerium-D Part 1 Drying Condition of the Leaves of Nerium-Odorum-D.Yakugaku Zasshi 92, 154-7.
Yamauchi T, Takahashi M, Abe F (1976) Cardiac Glycosides of the Root Bark of Nerium-Odorum. Phytochemistry, 15, 1275.
Yamauchi T, Takata N, Mimura T (1975) Cardiac Glycosides of the Leaves of Nerium odorum. Phytochemistry, 14, 1379-82.
Yarbrough B (1983) Plant poisoning : A comprehensive management guide. ER Reports 4, 13-18.
Yu MS, Lai SW, Lin KF, Fang JN, Yuen WH, Chang RC (2004) Characterization of polysaccharides from the flowers of Nerium indicum and their neuroprotective effects. International Journal of Mol Medicine,14(5), 917-924.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Ashima Gakhar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license unless indicated otherwise in a credit line to the material. If the material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/