Green Multicomponent method for synthesis of substituted derivatives 2-amino Chromenes by using Na2CO3 as a catalyst

Abstract

2-amino- 4H-chromenes represent an important class of compounds being the main component of many naturally occurring products. The basic structural frameworks of chromene for example is a common feature of many tannins and polyphenols found in tea, fruits vegetables and red wine. Derivatives of chromene are an important group of compounds found in plants including fruit and vegetables. chromene are biologically active with wide range of activities such as antimicrobial, mutagenicity, antiviral, antiproliferative and central nervous system activities. In this research work substituted 2-amino 4H-chromenes were synthesized by one pot synthesis method by interaction with substituted benzaldehyde, β-naphthol, and malononitrile by using sodium bicarbonate as catalyst. The yield of product is found to be very good. The synthesized compounds were recognized by IR, NMR and mass spectroscopic technique.