Identification of molecular markers associated with the progression and prognosis of Cardiomyopathy
Keywords:
Cardiomyopathy, HCM, DCM, MYH7, MYBPC3Abstract
Cardiomyopathy is one kind of Heart muscle disorder, which has a genetic cause and may lead to fatal heart strokes. Bioinformatics screening of related genes may be diagnosing tools which will help to finalize exact working out therapy. Apart from various other causes of heart muscle disorder, one most effective cause is Genetic. According to different researchers about 200 rare mutations in 20 different genes may lead to Cardiomyopathy; however its genetic etiology is largely unknown. Most common genes respective to this type of studies, specifically in focus are MYBPC3, MYH7, TNNT2 and TNNI3. In this study there is use of some bioinformatics tools to do comparative sequence analysis of lab sequenced data and data retrieved from Gene Bank, concluded considerable amount of mutations in lonely Intron 32 of MYBPC3 that is Cardiac muscle protein coding genes which may result in certain type of a Cardiomyopathy. In case if this study extended to gene sequencing or to the genome sequencing through this method, it will definitely be result in huge data, helpful for identification of molecular markers associated with prognosis and progression of not only cardiomyopathies but also other diseases too.
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