Role of apoptotic pathways in treating pancreatic cancer using natural compounds
Keywords:
Natural compounds, Anticancer, Apoptotic pathway, Heterogeneous diseaseAbstract
Pancreatic cancer is becoming most common cancer in the world wide having less treatment option with high death rate. Traditional compounds are chemical compounds isolated from natural/herbal plants. They have less side effects or no side effect and play an important role as anticancer agent in treatment. These having various natural compounds /substances that may involve in the action of different molecular pathways in apoptotic pathway like curcumin, capsaicin, triptolide, EGCG, ursolic acid etc. These natural compound having ability to suppress development of the pancreatic cancer by the mechanism of signaling pathways such as K-Ras, NFқB, MAPK, P12K, AKT, P53, JAK & STAT. This review deals with use of natural compounds as a source of anticancer with potential mechanisms of apoptotic pathways.
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