Design and development of Citronellea oil microemulsion for effectual topical delivery

Authors

  • Sharmila Naykar Sandip Institute of Pharmaceutical Sciences, Sandip Foundation, Mahiravani, Nashik, India
  • Gadakh Archana Sandip Institute of Pharmaceutical Sciences, Sandip Foundation, Mahiravani, Nashik, India
  • Deore Jidnyasad Sandip Institute of Pharmaceutical Sciences, Sandip Foundation, Mahiravani, Nashik, India

Keywords:

Microemulsion, Citronella oil, Topical delivery, Antifungal, Microemulsion based gel, Candida albicans

Abstract

The purpose of this study was to formulate topical microemulsion gel of citronella oil suitable for topical delivery. Citronella oil microemulsion system with Tween 20 as Surfactant , PEG 200 as cosurfactant and citronella oil as oil was developed for topical delivery. Pseudo ternary phase diagram were constructed to identify the microemulsion region and a suitable composition was identified to formulate the microemulsion. Single isotropic region, which is considered as an O/W microemulsion was found in the pseudo ternary phase diagram developed at various Tween 20 and PEG 200 ratio using phase titration method. The developed microemulsion was characterized for clarity, Zeta potential, Viscosity, Globule size. Centrifugation studies were carried out to confirm the stability of the developed formulation. The formulation was thickened with a gelling agent carbopol 940 and xanthum gum, to yield a gel with desirable properties facilitating the topical application. The developed microemulsion based gel was characterized for pH, Spreadability, Viscosity. Optimized microemulsion based gel formulation was found to exhibit significant antifungal activity against candida Albicans species.Thus the present study indicates that developed topical microemulsion gel of citronella oil effective for treatment of fungal infection.   

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References

Aboofazeli R, Patel N, Thomas, Lawerence MJ (1995) Investigations into the formation and characterization of phospholipid microemulsions. IV. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol and oil; the influence of oil, Int J Pharm, 125(1):107-116.

Chen HB, Chang XL, Weng T, (2004) A study of microemulsion systems for transdermal delivery of triptolide, J. Control. Rel, 98:427–436.

Goud K, Desai H (2004) Enhanced Skin Permeation of Rofecoxib using Topical Microemulsion Gel, Drug Development Research, 63: 33–40.

Harwansh RK, RahmanMd A, Dangi JS (2010) Microemulsion System for Transdermal delivery of Diclofenac Sodium for Bioavailability Enhancement India Journal of Pharmacy Research, 3(9):2182-2185.

Ibrahim SI, Hana A, Elham AK, Enam K, Martin K, Phillip JC(2013), Studies on the kinetics of killing and the proposed mechanism of action of microemulsions against fungi, Int. J. Pharm, ; 454(1): 226-32.

Kweon JH, Chi SC and Park ES (2004) Transdermal Delivery of Diclofenac gel Using Microemulsions, Arch. Pharm. Res. 27(3): 351–356.

Mandal S, Mandal SS, Sawant KK (2010) Design and development of microemulsion drug delivery system of atorvastatin and study its intestinal permeability in rats. Int.J Drug Del. 2010, 2:69-75.

Mohmed E, Ahmed A (2011) Formulation and evaluation of medicated microemulsion for topical application, Int. J. Novel Drug Deliv. Tech., 1(4): 208-212.

Park ES, Cui Y, Yun BJ, Ko IJ, Chi SC (2005) Transdermal Delivery of Piroxicam using Microemulsions, Arch. Pharm. Res.; 28(2), 243-248.

Salunkhe S, Thorat D, Mali S (2013) Formulation, development and evaluation of Davana oil based topical microemulsion, W. J. Pharm. and Pharm. Sci, 2013, 2(6):2725-2733.

Schhwarz JS, Weisspapir MR, Friedman DI (1995) Enhanced transdermal delivery of diazepam by submicron emulsion(SME) creams, pharm Res., 12(5): 687-92.

Shafiq S, Shakeel F, Khar R (2008) Enhanced Stability of Ramipril in Nanoemulsion Containing Cremophor- EL: A Technical Note, AAPS, Pharm Sci Tech. 2008; 9(4): 1097-1101.

Shah RR, Magdum CS, Patil SS, Niakwade NS (2010) Preparation and Evaluation of Aceclofenac Topical Microemulsion. Iranian Journal of Pharmaceutical Research, 9(1):5-11.

Talele SG, Gadhe LT, Hire P, Kapadi S and Chaudhari GN (2015) Formulation and evaluation of topical microemulsion gel of karanj oil, 2015. 35-40.

Talele Swati G and Gudsoorkar VR (2015) Novel approaches for solidification of SMEDDS, An international Journal of pharmaceutical biosciences, 4,2015, 90-107.

Trey SM, Wicks DA, Mididoddi PK, Repka MA (2007) Delivery of Itraconazole Extruded HPC Films, Drug Dev. Ind. Pharm, 33:727-735.

Wany A, Jha S, Kumar V, Panday D (2013) Chemical analysis and therapeutic uses of Citronella oil from cymbopogonwinterious, Int. J. Research, Vol.1: 504-521.

Watkinson AC, Hadgraft J, lane ME (2008) Application of Microemulsion in Dermal and transdermal Drug Dlivery Skin PharmacolPhysicol., 2008, 21:246-259.

Yin YM, Cui FD, Mu CF, Choi MK, Kim JS, Chung SJ, Shim CK, Kim DD (2009) Docetaxelmicroemulsion for enhanced oral bioavailability: Preparation andin vitro and in vivo evaluation, J. Control. Rel. 2009, 140(2): 86-94.

Yu A, Wang W, Dong R, Wu J, Zhai GX (2008) Formulation design of microemulsion for dermal delivery of penciclovir, Int. J. Pharm., 360:184-190.

Zabka M and Benkova M (1995) Microemulsions containing local anaesthetics. Part 6: Influence of microemulsion vehicle on in vivo effect of pentacaine, Pharmaziene 1995; 50: 703-704.

Zhu W, Guo C, Yu A, Gao Y, Cao F, Zhai X (2009) Microemulsion-based hydrogel formulation of penciclovir for topical delivery, Int. J. Pharm., 378:52-158.

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Published

2022-09-30

How to Cite

Sharmila Naykar, Gadakh Archana, & Deore Jidnyasad. (2022). Design and development of Citronellea oil microemulsion for effectual topical delivery. International Journal of Life Sciences, 10(3), 263–272. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/688

Issue

Vol. 10 No. 3 (2022): International Journal of Life Sciences

Section

Research Articles

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