Mitigation of radiation and mercury induced histological changes in the brain of Swiss albino mice by Moringa oliefera

Authors

  • Manisha Agarwal DR
  • Birbal Ram Radiation Biology Laboratory, Govt. Dungar College Bikaner (Raj.)
  • Archana Purohit, Radiation Biology Laboratory, Govt. Dungar College Bikaner (Raj.)
  •  Aruna Chakrawarti Radiation Biology Laboratory, Govt. Dungar College Bikaner (Raj.)
  • R.K. Purohit Radiation Biology Laboratory, Govt. Dungar College Bikaner (Raj.)

Keywords:

radiation, Mercury, mice, moringa, brain

Abstract

For the purpose of study male Swiss albino mice were divided into seven groups. The mice were exposed to gamma radiation (2.5 Gy and 5.0 Gy) and also provided mercuric chloride (0.5 ppm) both separately and combined. The herbal radioprotector Moringa was given to experimental groups after irradiation and mercury treatment. Animals were autopsied at post treatment interval of 1,2,4,7,14 and 28 days. After sacrificing the animal’s histopathology of Brain was observed. In the present investigation, qualitative changes reflect the thickening of menninges, hyperaemia, pycnotic nuclei and developmental retardation of the individual neurons in terms of shape and size, degeneration of connective tissue, deviation from normal cytoarchitecture of the neocortex and irregular arrangements of neurons. The histological changes differ in degree of severity with dose and changes were more pronounced in combined treatment groups. Moringa treated groups demonstrated early and fast onset of recovery in comparison to non-Moringa treated groups. The presence of various bioactive compound in MOE are efficacious in protection and prevention of damage in antioxidant defense system of brain.

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References

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Published

2022-12-31

How to Cite

Agarwal, M., Birbal Ram, Archana Purohit,  Aruna Chakrawarti, & R.K. Purohit. (2022). Mitigation of radiation and mercury induced histological changes in the brain of Swiss albino mice by Moringa oliefera. International Journal of Life Sciences, 10(4), 351–355. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/704

Issue

Vol. 10 No. 4 (2022): International Journal of Life Sciences

Section

Research Articles

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Copyright (c) 2022 Manisha Agarwal, Birbal Ram, Archana Purohit,,  Aruna Chakrawarti, R.K. Purohit

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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