The Effect of Paeonia lactiflora root on the Memory of Drosophila melanogaster with Autism Spectrum Disorder

Authors

  • Prajith Pandrate Academies of Loudoun

Keywords:

Autism Spectrum Disorder, Behavioral neuroscience, Paeonia lactiflora root, Drosophila melanogaster, memory retention

Abstract

Autism spectrum disorder (ASD) is a prevalent problem within the United States, with approximately 1 in 44 children diagnosed. The frontal cortex of ASD brains have 67% more neurons compared with control brains. Increased neuron accumulation negatively impacts memory, as the frontal cortex plays a critical role in tasks containing memory and cannot be overstimulated. Previous research found that Paeonia lactiflora root lowered neurotrophin levels (essential proteins for neuron survival) in the frontal cortex. Due to the connection between ASD and neuron levels, the purpose and novelty of this study is to determine the effect of P. lactiflora root on the memory retention of Drosophila melanogaster by using an Aversive Phototaxic Suppression Assay. The results of the study show a statistically significant difference (P-value = 0.0217) between ASD flies without the root in diet and ASD flies with the root in diet, indicating an increase in memory retention for the flies that were administered the extract. These findings support the original hypothesis that P. lactiflora root would increase memory retention in Drosophila with ASD. By better understanding the effect of P. lactiflora root on the memory retention of ASD, a treatment for this chronic disorder can be found.

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References

Banerjee S, Riordan M & Bhat MA (2016) Genetic aspects of autism spectrum disorders: insights from animal models. Frontiers in Cellular Neuroscience, 8. https://doi.org/10.3389/fncel.2016.00058

Centers for Disease Control and Prevention. (2022). Data and Statistics on Autism Spectrum Disorder. https://www.cdc.gov/ncbddd/autism/data.html.

Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC & Pierce K (2011) Neuron number and size in prefrontal cortex of children with autism. JAMA, 306(18), 2001–2010. https://doi.org/10.1001/jama.2011.1638.

Habib A, Harris L, Pollick F & Melville C (2019) A meta-analysis of working memory in individuals with autism spectrum disorders. PloS one, 14(4), e0216198. https://doi.org/10.1371/journal.pone.0216198 .

Lan Z, Chen L, Fu Q, Ji W, Wang S, Liang Z, Qu R, Kong L, & Ma S (2013) Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. Brain research, 1498, 9–19. https://doi.org/10.1016/j.brainres.2012.12.040.

Lavelle TA, Weinstein MC, Newhouse JP, Munir K, Kuhlthau K & Prosser LA (2019) Economic Burden of Childhood Autism Spectrum Disorders. Pediatrics, 133(3), e520–e529. https://doi.org/10.1542/peds.2019-0763.

Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W & Han J (2013) Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of neuroscience : The Official Journal of the Society for Neuroscience, 33(39), 15545–15554. https://doi.org/10.1523/JNEUROSCI.0819-13.2013.

Seugnet L, Suzuki Y, Stidd R & Shaw PJ (2009) Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster. Genes, brain, and behavior, 8(4), 377–389. ttps://doi.org/10.1111/j.1601-183X.2009.00483

Sulkowski MJ, Han TH, Ott C, Wang Q, Verheyen EM, Lippincott-Schwartz J & Serpe M (2016) A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction. PLOS Genetics, 12(1), e1005810. https://doi.org/10.1371/journal.pgen.1005810.

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Published

2023-09-30

How to Cite

Pandrate, P. (2023). The Effect of Paeonia lactiflora root on the Memory of Drosophila melanogaster with Autism Spectrum Disorder. International Journal of Life Sciences, 11(3), 249–256. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/796

Issue

Vol. 11 No. 3 (2023): International Journal of Life Sciences

Section

Research Articles

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Copyright (c) 2023 Prajith Pandrate

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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