Early onset of Alzheimer's is on the rise - Evidence and Implications
Keywords:
Alzheimer's, SSRIs, MDD, DietsAbstract
The prevalence of early-onset Alzheimer's Disease (AD) and Major Depressive Disorder (MDD) has demonstrated an escalating trajectory. This warrants an investigation into their intricate connections. This review will assess the relationship among AD, MDD, and their associated medication, specifically Selective Serotonin Reuptake Inhibitors (SSRIs). Our overarching hypothesis is that diet significantly contributes to depression by modulating tryptophan metabolism, and SSRIs can significantly stunt AD progression. Therefore, this review will examine three aspects: the biochemistry of depression and how it relates to the progression of AD; how diet is linked to MDD and whether this is predominant in a younger age range; and the potential effectiveness of the SSRIs fluoxetine (FLX) and citalopram as a treatment to inhibit AD pathology.
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