Evaluation of wound healing potential of polyherbal formulation in human subjects

Authors

  • Lalita Kushwah Department of Zoology, S.M.S. Govt. Model Science College, Gwalior, Madhya Pradesh, 474009, India
  • Rupali Dutt School of Studies in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh, 474001, India
  • Manisha Singh Department of Surgery, Gajra Raja Medical College, Gwalior, Madhya Pradesh, 474009 India
  • Sharma D.K. Department of Zoology, S.M.S. Govt. Model Science College, Gwalior, Madhya Pradesh, 474009, India

Keywords:

Polyherbal formulation, wound healing, hydroxyproline, hexosamine

Abstract

Tagetes erecta- flowers, Tridax procumbens- wholeplant, Azadirachta indica- leaves, Ficus benghalensis- bark, Curcuma longa- rhizomes and Aloe vera- leaves are popular all over the world for their medicinal values. The present study aimed to develop a polyherbal formulation and validate its wound-healing potential in human subjects. Selected plants parts were subjected to Soxhlet extraction individually. The phytochemical-based Formulation (ointment) was topically applied on the wounds of experimental human subjects. A significant (**p<0.01) rate of wound contraction was observed between the 10th day to the 50th day. However, the polyherbal formulation (5%) was found superior in human subjects, the wound was completely (100%) healed on 50th day followed by an evaluation of its biochemical parameters. Hydroxyproline (49.55%) and Hexosamine (41.74%) were also found significantly increase on 30th day. This study revealed that the 5% Polyherbal formulation holds immense therapeutic significance and can be extrapolated to diabetic wounds where delay in wound healing is a major issue.

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Published

2024-03-31

How to Cite

Lalita Kushwah, Rupali Dutt, Manisha Singh, & Sharma D.K. (2024). Evaluation of wound healing potential of polyherbal formulation in human subjects. International Journal of Life Sciences, 12(1), 99–104. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/913

Issue

Vol. 12 No. 1 (2024): International Journal of Life Sciences

Section

Research Articles

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Copyright (c) 2024 authors

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