Screening of Acetylcholinesterase inhibitors by Moringa olifera

Authors

  • Raje Sharayu Department of Botany. Bhavans College Andheri(W)
  • Mestry Asmita Department of Botany. Bhavans College Andheri(W)

Keywords:

Alzheimer’s Disease, Acetylcholinesterase, Inhibition, Zebrafish, Plant Extracts

Abstract

Acetylcholinesterase (AChE) is an enzyme involved in the breakdown of the neurotransmitter acetylcholine into acetic acid and choline. Inhibition of Acetylcholinesterase is needed for deceleration of neurodegeneration in Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Plants are known to contain Acetylcholinesterase inhibitors.The methanolic extracts of Moringa olifera leaves were checked for Acetylcholinesterase inhibition on the acetylcholinesterase from brain homogenate of Danio rerio. The activity of the enzyme in-vitro and in-vivo conditions. In our investigations the extract from the plant showed a reduction in the Acetylcholinesterase activity. Under in-vitro conditions and in-vivo conditions the activity of Acetylcholinesterase dropped by 29.26% and 34.26% respectively.

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Published

2016-07-23

How to Cite

Raje Sharayu, & Mestry Asmita. (2016). Screening of Acetylcholinesterase inhibitors by Moringa olifera. International Journal of Life Sciences, 4(2), 302–305. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/1314

Issue

Vol. 4 No. 2 (2016): International Journal of Life Sciences

Section

Short Communicaion

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Copyright (c) 2016 Authors

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