Beneficial effect of Moringa oleifera on Lead induced Oxidative stress

Authors

  • Raje Sharayu Department of Botany. Bhavans College Andheri (W), India
  • Mestry Asmita Department of Botany. Bhavans College Andheri (W), India

Keywords:

Lead toxicity, anti-cytotoxic, anti-hemolytic, Moringa oleifera leaves powder

Abstract

Moringa oleifera is a tree belonging to family Moringaceae. Its leaves and seeds are reported to have ameliorative effects against metal toxicity. Moringa oleifera leaves are used in many physiologically adverse conditions and are to be an excellent remedial agent; it needs to be studied comprehensively. In the present investigation, the phytochemical analysis, anti-cytotoxic and anti-hemolytic effect of Moringa oleifera leaf extract and crude flavonoid extract was tested against Lead acetate induced cytotoxicity in onion root tips and hemolysis in Human Blood Erythrocytes. The anti-cytotoxic and anti-hemolytic activity increases with increase in the concentration of leaf extract and flavonoid extract of Moringa oleifera.

Downloads

Download data is not yet available.

References

Alexa ID, Mihalache IL, Panaghiu L & Palade F (2002) Chronic lead poisoning- a" forgotten"cause of anemia. Rev. Med. Chir. Soc. Med. Nat. Iasi., 106(4):825-8,

Aruoma OI (1999) Free radicals, antioxidants and international nutrition. Asia Pac J Clin Nutr.;8: 53–63.

Asare GA, Gyan B, Bugyei K, Adje S, Mahama R, Addo P, Otu-Nyarko L, Wiredu EK, Nyarko A (2012) Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. J. Ethnopharmacol, 139:4265–272.

Bakare AA, Mosuro AA and Osibanjo O (2000) Effects of simulated leachate on chromosomes and mitosis in roots ofAllium cepa L.. Journal of Environmental Biology 213: 263 271.

Bont RD, van Larebeke N (2004) Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis.;3: 169–185.

Chitra K, Pillai KS (2002) Antioxidants in health. Indian J Physiol Pharmacol.;46: 1–5.

Coyle P, Kosnett MJ & Hipkins K (2005) Severe lead poisoning in the plastic industry: a report of three cases. Am. J. Ind. Med., 47(2):172-5.

Djeridane A, Yousfi M, Nadjemi B, Vidal N, Lesgards JF, Stocker P (2006) Screening of some Algerian medicinal plants for the phenolic compounds and their antioxidant activity. Eur Food Res Technol; 224:801-9. doi: 10.1007/s00217- 006-0361-6

Ebrahimzadeh MA, Nabavi SF, Nabavi SM, Eslami B (2010) Antihemolytic and antioxidant activities of Allium paradoxum. Cent Eur J Biol ;5:338-45. doi: 10.2478/ s11535-010-0013-5

Fahey JW (2005) Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. Trees for Life. ( 1): 1–33.

Fiskesjo G (1997) Allium test for screening chemicals; evaluation of cytologic parameters. In W Wang, J W Gorsuch and J S Hughes eds.. Plants for environmental studies. Boca Raton, New York: CRC Lewis Publisher,308 333.

Flynn TP, Allen DW, Johnson GJ, White JG (1983) Oxidant damage of the lipids and proteins of the erythrocyte membranes in unstable hemoglobin disease. Evidence for the role of lipid peroxidation. J Clin Invest;71:1215-23. doi: 10.1172/ JCI110870

Halliwell B (1997) Antioxidants and human disease: a general introduction. Nutr Rev.;5:544–552. Herbivores: Their Interaction with Secondary Plant Metabolites. New York 1979; Academic Press. p. 41.

Hershko C (2005) Lead poisoning by contaminated flour: anunfinished story. Harefuah., 144(7):458-528.

Hofmann, U. & Segewitz, G(1975) Influence of chelation therapy on acute lead intoxication in rats. Arch. Toxicol., 34(3):213-25.

Hong Y, Lin S, Jiang Y, Ashraf M (2008) Variation in contents of total phenolics and flavonoids and antioxidant activities in the leaves of 11 Eriobotrya species. Plant food Hum Nutr.;63: 200–204.

Kamat J P, Boloor K K, Devasagayam T P A, Venkatachalam S R (2000) Antioxidant properties of Asparagus racemosus against damage induced by gamma-radiation in rat liver mitochondria. J Ethnopharmacol.;71: 425–435.

Klauder DS and Petering HG (1977) Anemia of lead intoxication: A role of Copper. J. Nutr., 107(10):1779- 85.

Ko FN, Hsiao G, Kuo YH (1997) Protection of oxidative hemolysis by demethyldiisoeugenol in normal and beta-thalassemic red blood cells. Free Radic Biol Med;22:215-22. doi: 10.1016/j.fct.2006.04.006

Kohen R, Gati I (2000) Skin low MoLEcular weight antioxidants and their role in aging and in oxidative stress. Toxicol.;148: 149–157. Kumar S, Kumar D, Manjusha, Saroha K, Singh N, Vashishta B (2008) Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.) Schrad. methanolic fruit extract., Acta pharma., 58:215-220.

Lalas S; Gortzi O; Athanasiadis V; Tsaknis J and Chinou I (2012) Determination of antimicrobial activity and resistance to oxidation of Moringa peregrina seed oil. Molecules, 17: 2330–2334.

Mbikay M (2012) Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Front. Pharmacol, 3:1–12.

Mierlici D, Ghioghita G and Capraru G (2009) Some cytogenetic effects induced in barley by the treatments with hydroalcoholic rosemary extract,” Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași, Sectiunea II A: Genetica si Biologie Moleculara, vol. 10, pp. 57-61.

Mukunzi D, Nsor-Atindana J, Xiaoming Z, Gahungu A, Karangwa E and Mukamurezi G (2011) Comparison of volatile profile of Moringa oleifera leaves from Rwanda and China using HS-SPME. Pakistan J. Nutr,10: 602–608.

Naim M, Gestener B, Bondi A and Birk, Y (1976) Antioxidant and anti-hemolytic activities of soyabean isoflavones, J. Agric. Food. Chem. 24: 1174-1177.

Nhukarume L, Chikwambi Z, Muchuweti M, Chipurura B (2010) Phenolic content and antioxidant capacities of Parinari curatelifolia, Strychnos spinosa and Adansonia digitata. J Food Biochem.;34: 207–221.

Noori MM, Heidari Z, Mahmoudzadeh Sagheb H & Barbarestani M (2003) Effects of chronic lead acetate intoxication on blood indices of male adult rat. Daru. Pharm. J., 11(4): 147-5.

Othman AI, Al Sharawy S & El-Missiry MA (2004) Role of melatonin in ameliorating lead induced haematotoxicity. Pharmacol. Res., 50(3):301-7.

Rice-Evans C, Omorphos SC, Baysal E(1986)Sickle cell membranes and oxidative damage. Biochem J;237:265- 9. PMCID: PMC1146974

Roche A, Florkowski C & Walmsley T (2005) Lead poisoning due to ingestion of Indian herbal remedies. N. Z. Med. J., 118(1219):U1587. Saito K, Kohno M, Yoshizaki F, Niwano Y (2008) Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions. Plant Foods Hum Nutr.;63: 65–70.

Samariya Krishna and Sarin Renu (2013) Isolation and identification of flavonoids from cyperus rotundus linn. In vivo and in vitro journal of drug delivery & therapeutics;, 3(2), 109-113 109 © 2011, jddt

Shannon M, Graef J & Lovejoy FHJr (1988) Efficacy and toxicity of D-penicillamine in low-level lead poisoning. J. Pediatr., 112(5):799-804.

Sofowora A (1993) Medicinal Plants and Traditional Medicine in Africa.Spectrum Books Ltd., Ibadan, Nigeria, pp. 191-289.

Sreenivasa Rao, P. and K.S Parekh, 1981. Phycology, J., 9: 353-361.

Steinitz B, Tabib Y, Gaba V, Gefen T and VakninY (2009) Vegetative micro-cloning to sustain biodiversity of threatened Moringa species. In Vitro Cell. Dev. Biol.-Plantm 45: 65–71.

Subramanian SS and Nagarajan (1969) Flavonoids of seeds of Crotolaria retusa and C.Straita Current Science. 38:365

Toplan S, Ozcelik D, Gulyasar T & Akyolcu MC (2004) Changes in hemorheological parameters due to lead exposure in female rats. J. Trace. Elem. Med. Biol.,18(2):179-82,

Tuormaa TE (1995) The adverse effects of lead. J. Orthomol. Med., 10(3-4):149-64.

Vig EK & HU H (2000)Lead toxicity in older adults. J. Am. Geriatr. Soc., 48(11):1501-6 .

Wangensteen H, Samuelsen AB, Malterud KE (2204) Antioxidant activity in extracts from coriander. Food Chem.;88: 293–297.

Yang H, Chen S, Chang N, Chang J, Lee M, Tsai P, Fu HH, Kao WW, Chiang HC, Wang HH, Hseu YC (2006) Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes. Food Chem Toxicol;44:1513-21. PMID: 16765500

Yu L (2001) Free radical scavenging properties of conjugated linoleic acids. J Agric Food Chem;49:3452-6. doi: 10.1021/jf010172v.

Downloads

Published

2017-04-06

How to Cite

Raje Sharayu, & Mestry Asmita. (2017). Beneficial effect of Moringa oleifera on Lead induced Oxidative stress. International Journal of Life Sciences, 5(1), 63–72. Retrieved from https://ijlsci.in/ls/index.php/home/article/view/1360