Reliance of tumor growth and associated angiogenesis on glutamine-an overview
Keywords:
glutamine, tumor, angiogenesisAbstract
Tumor-bearing state is accompanied by changes in host as well as cancer cell metabolism of several amino acids. Among these amino acids, glutamine holds a special position in tumor cell metabolism as it is an abundant and versatile nutrient that takes part in multiple cellular processes. It not only participates in energy production, but also contributes to redox homeostasis, signaling and macromolecular synthesis within cancer cells. Being an important component of the extracellular matrix protein, fibrin, glutamine is also known to contribute to tumor-induced angiogenesis. The diverse regulatory roles played by this amino-acid makes it a desirable therapeutic target in cancer. The present study throws light on the various aspects of glutamine metabolism in cancer cells and the future prospects of diagnostic and therapeutic strategies that can be deployed in this arena.
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